Imaging Instructions for Visualization of Vessels, Blood Flow and Tissue Perfusion Immediately switch the access on the stopcock and inject the prepared flush. Inject the prepared SPY AGENT GREEN into the line as a tight bolus. Prior to the imaging procedure, draw up the desired dosage of SPY AGENT GREEN solution into appropriate syringes and prepare a 10 mL syringe of 0.9% Sodium Chloride, USP.Īdminister via a central or peripheral venous line using a three-way stopcock attached to an injection port on the infusion line.
Do not exceed the maximum total dose of 2 mg/kg. Adjust the amount and type of flush to avoid volume and/or sodium overload.Īdditional doses may be administered to obtain imaging sequences during the procedure.
Lower doses may be administered in younger patients and in those with lower body weight. The recommended dose for a single image sequence is 1.25 mg to 5 mg SPY AGENT GREEN of a 2.5 mg/mL solution. Immediately flush with a 10 mL bolus of 0.9% Sodium Chloride, USP. The recommended dose of SPY AGENT GREEN for a single image sequence is 1.25 mg to 5 mg of a 2.5 mg/mL solution.įor visualization of perfusion in extremities through the skin, the recommended dose is 3.75 mg to 10 mg of a 2.5 mg/mL solution. Recommended Dose and Administration for Visualization of Vessels, Blood Flow and Tissue Perfusion
It has a pH of 5-7 and an osmotic pressure ratio to physiological saline of about 0.01 when 1 vial of Spy Agent Green is dissolved in 5 mL water for injection (0.5% aqueous solution). Its melting point is 230☌ (decomposition). Spy Agent Green is unstable in aqueous solution but is stable in the solutions containing protein or in the dry form. Spy Agent Green is a dark, green-blue, odorless, lump, soluble in water or methanol and practically insoluble in acetone. Its empirical formula is C 43H 47N 2NaO 6S 2 and molecular weight is 774.96. Spy Agent Green is 2- indolin-2-ylidene]-1, 3, 5-heptatrienyl]-1, 1- (dimethyl-3-(4-sulfobutyl)-1 H-benzindolium hydroxide, inner salt, sodium salt. For Determining Cardiac Output, Hepatic Function and Liver Blood Flow
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